1rqa Summary

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Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions

The structure was published by Chan, N.-L., Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2004 in a paper entitled "Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.11 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch bicarbonate transportsearch positive regulation of cell deathsearch transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch protein bindingsearch oxygen transporter activitysearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch extracellular regionsearch blood microparticlesearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch cytosolsearch membranesearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) hydrogen peroxide catabolic processsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch platelet aggregationsearch renal absorptionsearch positive regulation of cell deathsearch protein heterooligomerizationsearch small molecule metabolic processsearch transportsearch nitric oxide transportsearch regulation of blood vessel sizesearch blood coagulationsearch regulation of blood pressuresearch oxygen transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch