1rq3 Summary

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Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin

The structure was published by Chan, N.L., Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2004 in a paper entitled "Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular regionsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch cytosolsearch membranesearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch transportsearch protein heterooligomerizationsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch
B, D (P68871) cytosolsearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch regulation of blood vessel sizesearch oxygen transportsearch transportsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood pressuresearch positive regulation of cell deathsearch renal absorptionsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch metal ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch peroxidase activitysearch heme bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch