1rq3 Summary

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Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin

The structure was published by Chan, N.L., Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2004 in a paper entitled "Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch metal ion bindingsearch protein bindingsearch iron ion bindingsearch peroxidase activitysearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch
B, D (P68871) oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch haptoglobin bindingsearch positive regulation of cell deathsearch oxygen transportsearch renal absorptionsearch bicarbonate transportsearch regulation of blood vessel sizesearch regulation of blood pressuresearch protein heterooligomerizationsearch blood coagulationsearch small molecule metabolic processsearch platelet aggregationsearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch