1rne Summary

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THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR

The structure was published by Rahuel, J., Priestle, J.P., and Grutter, M.G., in 1991 in a paper entitled "The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of RENIN. This molecule has the UniProt identifier P00797 (RENI_HUMAN)search. The sample contained 340 residues which is < 90% of the natural sequence. Out of 340 residues 325 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RENIN P00797 (67-406) (RENI_HUMAN)search Homo sapienssearch 100% 340 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00797 (67 - 406) RENIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00797) Pepsin-likesearch Acid Proteasessearch PF00026: Eukaryotic aspartyl proteasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P00797) proteolysissearch aspartic-type endopeptidase activitysearch

Chain InterPro annotation
A Aspartic peptidasesearch Aspartic peptidase, active sitesearch Aspartic peptidase domainsearch