› 1rlf

Solution NMR

STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1rlf/pdb
PDB entry 1rlf coloured by chain, ensemble of 10 models, front view.
PDB entry 1rlf coloured by chain, ensemble of 10 models, side view.
PDB entry 1rlf coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.
Esser D, Bauer B, Wolthuis RM, Wittinghofer A, Cool RH, Bayer P
Biochemistry 37 13453-62 (1998)
PMID: 9753431

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178869 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ral guanine nucleotide dissociation stimulator-like 2 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.05 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61193 (Residues: 646-735; Coverage: 12%)
Gene names: Rab2l, Rgl2, Rlf
Sequence domains: Ras association (RalGDS/AF-6) domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

7 review citations

Distinct requirements for Ras oncogenesis in human versus mouse cells.
Hamad et al. (2002)
6 more

3 mentions without citation

Stretching to understand proteins - a survey of the protein data bank.
SuĊ‚kowska et al. (2008)
2 more