1rkc Summary

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Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)

The structure was published by Izard, T., Evans, G., Borgon, R.A., Rush, C.L., Bricogne, G., and Bois, P.R., in 2004 in a paper entitled "Vinculin activation by talin through helical bundle conversion" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Talin.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (1-258) (VINC_HUMAN)search Homo sapienssearch 94% 262 98%
B Talin P54939 (1944-1969) (TLN1_CHICK)search Gallus gallussearch < 90% 26 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 258) Vinculin Homo sapiens
P54939 (1944 - 1969) Talin Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P18206) alpha-catenin/vinculinsearch vbs2 fragment of talinsearch, Four Helix Bundle (Hemerythrin (Met), subunit A)search PF01044: Vinculin familysearch
B Vinculin Binding Sitesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P18206) structural molecule activitysearch actin cytoskeletonsearch cell adhesionsearch
B (P54939) structural molecule activitysearch actin cytoskeletonsearch cytoskeletal anchoring at plasma membranesearch cell adhesionsearch

Chain InterPro annotation
A Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch
B Vinculin/alpha-cateninsearch Vinculin-binding site-containing domainsearch