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PDBe Entry: 1rgy 
Citrobacter freundii GN346 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime
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hydrolase
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X-RAY DIFFRACTION
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Resolution: 1.52 Å, R-factor: 19.7%, Free R-factor: 21.7%, Spacegroup: P 21 21 21
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06/04/2004, deposition: 13/11/2003, last revision: 24/02/2009
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Nukaga, M.; Kumar, S.; Nukaga, K.; Pratt, R.F.; Knox, J.R.
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Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes.
J.BIOL.CHEM. vol:279, pag:9344-9352 (2004) [PubMed ID 14660590 ]
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hydrolase, cephalosporinase, enzyme inhibition, phosphonate, beta-lactam antibiotics, drug design
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3.5.2.6 ExPASy BRENDA (A)
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Citrobacter freundii 546(A)
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Beta-lactamase precursor (EC 3.5.2.6) (Cephalosporinase) P05193 (A)
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A
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| A |
beta-lactamase |
Protein |
P05193 (AMPC_CITFR)
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360 |
100% |
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| A |
{[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID |
PTX
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| A |
(4S)-2-METHYL-2,4-PENTANEDIOL |
MPD
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