1raz Summary

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THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE

The structure was published by Jonsson, B.M., Hakansson, K., and Liljas, A., in 1993 in a paper entitled "The structure of human carbonic anhydrase II in complex with bromide and azide." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch response to steroid hormonesearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of bone resorptionsearch regulation of anion transportsearch response to organic substancesearch morphogenesis of an epitheliumsearch response to pHsearch secretionsearch regulation of chloride transportsearch response to zinc ionsearch apical part of cellsearch cytoplasmsearch plasma membranesearch axonsearch extracellular vesicular exosomesearch cytosolsearch membranesearch extracellular spacesearch basolateral plasma membranesearch myelin sheathsearch microvillussearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch