1r78 Summary


CDK2 complex with a 4-alkynyl oxindole inhibitor

The structure was published by Luk, K.-C., Simcox, M.E., Schutt, A., et al., DePinto, W., Dunten, P., and Dermatakis, A., in 2004 in a paper entitled "A new series of potent oxindole inhibitors of CDK2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 273 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein serine/threonine kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch histone kinase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch metal ion bindingsearch protein phosphorylationsearch phosphorylationsearch positive regulation of transcription, DNA-dependentsearch DNA replicationsearch cell cyclesearch DNA repairsearch positive regulation of cell proliferationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to nitric oxidesearch meiosissearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch response to DNA damage stimulussearch mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch cell divisionsearch histone phosphorylationsearch regulation of gene silencingsearch centrosome duplicationsearch blood coagulationsearch G2/M transition of mitotic cell cyclesearch mitotic G2 phasesearch Ras protein signal transductionsearch mitosissearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch nucleoplasmsearch cytoplasmsearch X chromosomesearch cytosolsearch cytoskeletonsearch nucleussearch chromosome, telomeric regionsearch Cajal bodysearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch condensed chromosomesearch endosomesearch transcription factor complexsearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch