1r5i

X-ray diffraction
2.6Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-135333 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 181 amino acids
Theoretical weight: 21.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
Hemagglutinin HA1 chain Chains: C, G
Molecule details ›
Chains: C, G
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/swine/Hong Kong/81/1978(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P11133 (Residues: 306-318; Coverage: 2%)
Gene name: HA
Superantigen Chains: D, H
Molecule details ›
Chains: D, H
Length: 216 amino acids
Theoretical weight: 25.59 KDa
Source organism: Metamycoplasma arthritidis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q48898 (Residues: 26-238; Coverage: 90%)
Sequence domains: Mycoplasma arthritidis-derived mitogen
Structure domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: I222
Unit cell:
a: 138.286Å b: 178.814Å c: 179.554Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.246
Expression systems:
  • Escherichia coli
  • Not provided
  • Escherichia coli BL21(DE3)