1r4f Summary

pdbe.org/1r4f
spacer

Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma vivax: Trp260Ala Mutant In Complex With 3-Deaza-Adenosine

The structure was published by Versees, W., Loverix, S., Vandemeulebroucke, A., Geerlings, P., and Steyaert, J., in 2004 in a paper entitled "Leaving group activation by aromatic stacking: an alternative to general Acid catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of IAG-nucleoside hydrolase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A IAG-nucleoside hydrolase Q9GPQ4 (2-327) (Q9GPQ4_TRYVI)search Trypanosoma vivaxsearch 100% 339 92%
B IAG-nucleoside hydrolase Q9GPQ4 (2-327) (Q9GPQ4_TRYVI)search Trypanosoma vivaxsearch 100% 339 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9GPQ4 (2 - 327) IAG-nucleoside hydrolase Trypanosoma vivax

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q9GPQ4) Nucleoside hydrolasesearch Inosine-uridine Nucleoside N-ribohydrolase, chain Asearch PF01156: Inosine-uridine preferring nucleoside hydrolasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9GPQ4) hydrolase activitysearch metal ion bindingsearch metabolic processsearch

Chain InterPro annotation
A, B Inosine/uridine-preferring nucleoside hydrolase domainsearch Inosine/uridine-preferring nucleoside hydrolasesearch