1r3c Summary



The structure was published by Patel, S.B., Cameron, P.M., Frantz-Wattley, B., O'Neill, E., Becker, J.W., and Scapin, G., in 2004 in a paper entitled "Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 348 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) positive regulation of reactive oxygen species metabolic processsearch positive regulation of protein import into nucleussearch MyD88-independent toll-like receptor signaling pathwaysearch gene expressionsearch response to stresssearch apoptotic processsearch blood coagulationsearch toll-like receptor 4 signaling pathwaysearch regulation of transcription, DNA-dependentsearch phosphorylationsearch protein phosphorylationsearch activation of MAPK activitysearch chondrocyte differentiationsearch positive regulation of erythrocyte differentiationsearch osteoclast differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch chemotaxissearch fatty acid oxidationsearch MyD88-dependent toll-like receptor signaling pathwaysearch platelet activationsearch 3'-UTR-mediated mRNA stabilizationsearch response to lipopolysaccharidesearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of transcription from RNA polymerase II promotersearch signal transductionsearch TRIF-dependent toll-like receptor signaling pathwaysearch DNA damage checkpointsearch cellular response to ionizing radiationsearch toll-like receptor 9 signaling pathwaysearch toll-like receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch skeletal muscle tissue developmentsearch MAPK cascadesearch cellular component movementsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch peptidyl-serine phosphorylationsearch toll-like receptor 2 signaling pathwaysearch striated muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of muscle cell differentiationsearch toll-like receptor 3 signaling pathwaysearch intracellular protein kinase cascadesearch toll-like receptor 5 signaling pathwaysearch transcription, DNA-dependentsearch stress-induced premature senescencesearch Ras protein signal transductionsearch lipopolysaccharide-mediated signaling pathwaysearch RNA metabolic processsearch response to DNA damage stimulussearch stress-activated MAPK cascadesearch response to muramyl dipeptidesearch muscle cell differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch signal transduction in response to DNA damagesearch angiogenesissearch toll-like receptor 10 signaling pathwaysearch cell morphogenesissearch regulation of sequence-specific DNA binding transcription factor activitysearch cell surface receptor signaling pathwaysearch glucose metabolic processsearch innate immune responsesearch mRNA metabolic processsearch protein bindingsearch MAP kinase activitysearch MAP kinase kinase activitysearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch nucleotide bindingsearch cytosolsearch nucleussearch nucleoplasmsearch spindle polesearch mitochondrionsearch cellsearch cytoplasmsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch