1r30 Summary

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The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme

The structure was published by Berkovitch, F., Nicolet, Y., Wan, J.T., Jarrett, J.T., and Drennan, C.L., in 2004 in a paper entitled "Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Biotin synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Biotin synthase P12996 (2-346) (BIOB_ECOLI)search Escherichia coli K-12search 100% 369 84%
B Biotin synthase P12996 (2-346) (BIOB_ECOLI)search Escherichia coli K-12search 100% 369 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12996 (2 - 346) Biotin synthase Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P12996) Biotin synthasesearch Aldolase class Isearch PF04055: Radical SAM superfamilysearch, PF06968: Biotin and Thiamin Synthesis associated domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P12996) biotin biosynthetic processsearch iron ion bindingsearch iron-sulfur cluster bindingsearch 4 iron, 4 sulfur cluster bindingsearch transferase activitysearch catalytic activitysearch biotin synthase activitysearch protein bindingsearch 2 iron, 2 sulfur cluster bindingsearch metal ion bindingsearch

Chain InterPro annotation
A, B Biotin synthase/Biotin biosynthesis bifunctional protein BioABsearch Elongator protein 3/MiaB/NifBsearch Radical SAMsearch Biotin and thiamin synthesis-associated domainsearch Aldolase-type TIM barrelsearch Biotin synthasesearch