1r2z Summary

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MutM (Fpg) bound to 5,6-dihydrouracil (DHU) containing DNA

The structure was published by Fromme, J.C. and Verdine, G.L., in 2003 in a paper entitled "DNA Lesion Recognition by the Bacterial Repair Enzyme MutM." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*TP*CP*CP*AP*(DHU)P*GP*TP*CP*TP*AP*CP*C)-3', and MutM.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MutM P84131 (1-274) (P84131_GEOSE)search Geobacillus stearothermophilussearch 93% 274 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P84131 (1 - 274) MutM Geobacillus stearothermophilus

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P84131) Middle domain of MutM-like DNA repair proteinssearch, N-terminal domain of MutM-like DNA repair proteinssearch, C-terminal, Zn-finger domain of MutM-like DNA repair proteinssearch PF01149: Formamidopyrimidine-DNA glycosylase N-terminal domainsearch, PF06827: Zinc finger found in FPG and IleRSsearch, PF06831: Formamidopyrimidine-DNA glycosylase H2TH domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P84131) lyase activitysearch catalytic activitysearch DNA-(apurinic or apyrimidinic site) lyase activitysearch zinc ion bindingsearch nucleic acid bindingsearch hydrolase activity, hydrolyzing N-glycosyl compoundssearch oxidized purine nucleobase lesion DNA N-glycosylase activitysearch damaged DNA bindingsearch hydrolase activitysearch DNA bindingsearch metal ion bindingsearch hydrolase activity, acting on glycosyl bondssearch DNA repairsearch base-excision repairsearch DNA catabolic process, endonucleolyticsearch nucleotide-excision repairsearch cellular response to DNA damage stimulussearch metabolic processsearch

Chain InterPro annotation
A DNA glycosylase/AP lyasesearch Zinc finger, DNA glycosylase/AP lyase-typesearch Zinc finger, DNA glycosylase/AP lyase/isoleucyl tRNA synthetasesearch Ribosomal protein S13-like, H2THsearch DNA glycosylase/AP lyase, catalytic domainsearch DNA glycosylase/AP lyase, H2TH DNA-bindingsearch DNA glycosylase/AP lyase, zinc finger domain, DNA-binding sitesearch Formamidopyrimidine-DNA glycosylasesearch