1r2y Summary


MutM (Fpg) bound to 8-oxoguanine (oxoG) containing DNA

The structure was published by Fromme, J.C. and Verdine, G.L., in 2003 in a paper entitled "DNA Lesion Recognition by the Bacterial Repair Enzyme MutM." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.34 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', and MutM.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MutM P84131 (1-274) (P84131_GEOSE)search Geobacillus stearothermophilussearch 93% 274 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P84131 (1 - 274) MutM Geobacillus stearothermophilus

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P84131) Middle domain of MutM-like DNA repair proteinssearch, N-terminal domain of MutM-like DNA repair proteinssearch, C-terminal, Zn-finger domain of MutM-like DNA repair proteinssearch PF01149: Formamidopyrimidine-DNA glycosylase N-terminal domainsearch, PF06827: Zinc finger found in FPG and IleRSsearch, PF06831: Formamidopyrimidine-DNA glycosylase H2TH domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P84131) DNA-(apurinic or apyrimidinic site) lyase activitysearch hydrolase activity, hydrolyzing N-glycosyl compoundssearch zinc ion bindingsearch catalytic activitysearch hydrolase activitysearch oxidized purine nucleobase lesion DNA N-glycosylase activitysearch DNA bindingsearch hydrolase activity, acting on glycosyl bondssearch damaged DNA bindingsearch nucleic acid bindingsearch lyase activitysearch metal ion bindingsearch DNA catabolic process, endonucleolyticsearch cellular response to DNA damage stimulussearch metabolic processsearch DNA repairsearch nucleotide-excision repairsearch base-excision repairsearch

Chain InterPro annotation
A DNA glycosylase/AP lyasesearch Zinc finger, DNA glycosylase/AP lyase-typesearch Zinc finger, DNA glycosylase/AP lyase/isoleucyl tRNA synthetasesearch Ribosomal protein S13-like, H2THsearch DNA glycosylase/AP lyase, catalytic domainsearch DNA glycosylase/AP lyase, H2TH DNA-bindingsearch DNA glycosylase/AP lyase, zinc finger domain, DNA-binding sitesearch Formamidopyrimidine-DNA glycosylasesearch