Structure analysis

Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to the synthetic agonist BYI06830

X-ray diffraction
3Å resolution
Source organism: Heliothis virescens
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero dimer
Accessible surface area: 21129.48 Å2
Buried surface area: 4782.45 Å2
Dissociation area: 1,174.39 Å2
Dissociation energy (ΔGdiss): 2.21 kcal/mol
Dissociation entropy (TΔSdiss): 12.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127580
Assembly 2
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 40316.88 Å2
Buried surface area: 11513.53 Å2
Dissociation area: 2,348.85 Å2
Dissociation energy (ΔGdiss): 3.05 kcal/mol
Dissociation entropy (TΔSdiss): 26.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127581

Macromolecules

Chain: A
Length: 263 amino acids
Theoretical weight: 29.95 KDa
Source organism: Heliothis virescens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7SIF6 (Residues: 3-264; Coverage: 99%)
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

Search similar proteins

Chain: D
Length: 265 amino acids
Theoretical weight: 30.21 KDa
Source organism: Heliothis virescens
Expression system: Escherichia coli
UniProt:
  • Canonical: O18473 (Residues: 306-342, 343-550; Coverage: 43%)
Gene names: EcR, NR1H1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

Search similar proteins