1r1y Summary

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Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom

The structure was published by Abdulmalik, O., Safo, M.K., Lerner, N.B., et al., Santacroce, R., Abraham, D.J., and Asakura, T., in 2004 in a paper entitled "Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) extracellular vesicular exosomesearch endocytic vesicle lumensearch hemoglobin complexsearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch blood microparticlesearch bicarbonate transportsearch oxygen transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch
B, D (P68871) extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch response to hydrogen peroxidesearch blood coagulationsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch platelet aggregationsearch renal absorptionsearch nitric oxide transportsearch protein heterooligomerizationsearch regulation of blood pressuresearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch oxidation-reduction processsearch small molecule metabolic processsearch haptoglobin bindingsearch protein bindingsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch