1r1w Summary

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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET

The structure was published by Schiering, N., Knapp, S., Marconi, M., et al., Perego, R., Rusconi, L., and Cristiani, C., in 2003 in a paper entitled "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of HEPATOCYTE GROWTH FACTOR RECEPTOR. This molecule has the UniProt identifier P08581 (MET_HUMAN)search. The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 286 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEPATOCYTE GROWTH FACTOR RECEPTOR P08581 (1049-1360) (MET_HUMAN)search Homo sapienssearch < 90% 312 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08581 (1049 - 1360) HEPATOCYTE GROWTH FACTOR RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P08581) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch