› 1r1w

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET

Released:
DOI: 10.2210/pdb1r1w/pdb
PDB entry 1r1w coloured by chain, front view.
PDB entry 1r1w coloured by chain, side view.
PDB entry 1r1w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.
Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C
Proc Natl Acad Sci U S A 100 12654-9 (2003)
PMID: 14559966

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08581 (Residues: 1049-1360; Coverage: 23%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 43.038Å b: 46.028Å c: 158.448Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.204
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

Targeting MET in cancer: rationale and progress.
Gherardi et al. (2012)
26 more

11 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
10 more