1r1q Summary


Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads

The structure was published by Cho, S., Velikovsky, C.A., Swaminathan, C.P., Houtman, J.C., Samelson, L.E., and Mariuzza, R.A., in 2004 in a paper entitled "Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GRB2-related adaptor protein 2 and LAT pY191 peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GRB2-related adaptor protein 2 O89100 (50-147) (GRAP2_MOUSE)search Mus musculussearch < 90% 100 100%
B GRB2-related adaptor protein 2 O89100 (50-147) (GRAP2_MOUSE)search Mus musculussearch < 90% 100 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O89100 (50 - 147) GRB2-related adaptor protein 2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch