1r1k Summary

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Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to ponasterone A

The structure was published by Billas, I.M.L., Iwema, T., Garnier, J.M., Mitschler, A., Rochel, N., and Moras, D., in 2003 in a paper entitled "Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ecdysone receptor and ULTRASPIRACLE PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
D Ecdysone receptor O18473 (305-342) (ECR_HELVI)search ,
O18473 (343-550) (ECR_HELVI)search
Heliothis virescenssearch ,
Heliothis virescenssearch
< 90% ,
< 90%
266 88%
A ULTRASPIRACLE PROTEIN Q7SIF6 (3-264) (Q7SIF6_HELVI)search Heliothis virescenssearch 99% 263 91%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O18473 (305 - 342) Ecdysone receptor Heliothis virescens
Q7SIF6 (3 - 264) ULTRASPIRACLE PROTEIN Heliothis virescens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
A (Q7SIF6) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
D (O18473) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid bindingsearch ecdysteroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-dependentsearch steroid hormone mediated signaling pathwaysearch ecdysone receptor-mediated signaling pathwaysearch
A (Q7SIF6) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch zinc ion bindingsearch protein bindingsearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-dependentsearch transcription, DNA-dependentsearch

Chain InterPro annotation
D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Ecdysteroid receptorsearch Nuclear hormone receptor, ligand-bindingsearch
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch