1r0o Summary

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Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex

The structure was published by Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., and Rastinejad, F., in 2003 in a paper entitled "Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.24 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ultraspiracle protein P20153 (94-179) (USP_DROME)search Drosophila melanogastersearch < 90% 86 88%
B Ecdysone receptor P34021 (256-364) (ECR_DROME)search Drosophila melanogastersearch < 90% 109 71%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P20153 (94 - 179) Ultraspiracle protein Drosophila melanogaster
P34021 (256 - 364) Ecdysone receptor Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search
B Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P20153) nucleussearch regulation of transcription, DNA-templatedsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch zinc ion bindingsearch
B (P34021) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone receptor activitysearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, nuclear hormone receptor-typesearch Nuclear hormone receptor, ligand-bindingsearch Zinc finger, NHR/GATA-typesearch