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Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex

X-ray diffraction
2.24Å resolution
PDB entry 1r0o coloured by chain, front view.
PDB entry 1r0o coloured by chain, side view.
PDB entry 1r0o coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ecdysone receptor and Protein ultraspiracle and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 13400.08 Å2
Buried surface area: 5294.52 Å2
Dissociation area: 1,103.3 Å2
Dissociation energy (ΔGdiss): 2.84 kcal/mol
Dissociation entropy (TΔSdiss): 11.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114485

Macromolecules

Protein ultraspiracle
Chain: A
Length: 86 amino acids
Theoretical weight: 10.09 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20153 (Residues: 94-179; Coverage: 17%)
Gene names: CG4380, Cf1, NR2B4, usp
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor
Protein ultraspiracle in PDB entry 1r0o, assembly 1, front view.
Protein ultraspiracle in PDB entry 1r0o, assembly 1, side view.
Protein ultraspiracle in PDB entry 1r0o, assembly 1, top view.
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Ecdysone receptor
Chain: B
Length: 109 amino acids
Theoretical weight: 12.55 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P34021 (Residues: 256-364; Coverage: 12%)
Gene names: CG1765, EcR, NR1H1
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor
Ecdysone receptor in PDB entry 1r0o, assembly 1, front view.
Ecdysone receptor in PDB entry 1r0o, assembly 1, side view.
Ecdysone receptor in PDB entry 1r0o, assembly 1, top view.
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DNA chain C
Name: Ecdysone Response Element
Representative chains: C
Length: 18 nucleotides
Theoretical weight: 5.5 KDa
Ecdysone Response Element in PDB entry 1r0o, assembly 1, front view.
Ecdysone Response Element in PDB entry 1r0o, assembly 1, side view.
Ecdysone Response Element in PDB entry 1r0o, assembly 1, top view.
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DNA chain D
Name: Ecdysone Response Element
Representative chains: D
Length: 18 nucleotides
Theoretical weight: 5.49 KDa
Ecdysone Response Element in PDB entry 1r0o, assembly 1, front view.
Ecdysone Response Element in PDB entry 1r0o, assembly 1, side view.
Ecdysone Response Element in PDB entry 1r0o, assembly 1, top view.
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