1r0n Summary

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Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex

The structure was published by Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., and Rastinejad, F., in 2003 in a paper entitled "Structure of the heterodimeric Ecdysone Receptor DNA-binding complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Retinoic acid receptor RXR-alpha P19793 (130-206) (RXRA_HUMAN)search Homo sapienssearch 98% 81 96%
B Ecdysone receptor P34021 (256-364) (ECR_DROME)search Drosophila melanogastersearch < 90% 109 78%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (130 - 206) Retinoic acid receptor RXR-alpha Homo sapiens
P34021 (256 - 364) Ecdysone receptor Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P19793) Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch PF00105: Zinc finger, C4 type (two domains)search
B Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search
Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, nuclear hormone receptor-typesearch Nuclear hormone receptor, ligand-bindingsearch Zinc finger, NHR/GATA-typesearch