› 1r03

X-ray diffraction
1.7Å resolution

crystal structure of a human mitochondrial ferritin

Released:
DOI: 10.2210/pdb1r03/pdb
PDB entry 1r03 coloured by chain, front view.
PDB entry 1r03 coloured by chain, side view.
PDB entry 1r03 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala.
Langlois d'Estaintot B, Santambrogio P, Granier T, Gallois B, Chevalier JM, Précigoux G, Levi S, Arosio P
J Mol Biol 340 277-93 (2004)
PMID: 15201052

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N4E7 (Residues: 61-242; Coverage: 75%)
Gene name: FTMT
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

1 bound ligand:
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: F432
Unit cell:
a: 181.41Å b: 181.41Å c: 181.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.17 0.2
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Intracellular iron transport and storage: from molecular mechanisms to health implications.
MacKenzie et al. (2008)
11 more

6 mentions without citation

Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication.
Bou-Abdallah et al. (2018)
5 more