1qz7 Summary


Beta-catenin binding domain of Axin in complex with beta-catenin

The structure was published by Xing, Y., Clements, W.K., Kimelman, D., and Xu, W., in 2003 in a paper entitled "Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the {beta}-catenin destruction complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Beta-catenin and Axin.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta-catenin P35222 (133-665) (CTNB1_HUMAN)search Homo sapienssearch < 90% 533 98%
B Axin Q9YGY0 (435-504) (AXIN1_XENLA)search Xenopus laevissearch < 90% 70 24%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35222 (133 - 665) Beta-catenin Homo sapiens
Q9YGY0 (435 - 504) Axin Xenopus laevis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B Axin beta-catenin binding domainsearch
Chain InterPro annotation
A Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B Axin beta-catenin bindingsearch