1qym Summary

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X-ray structure of human gankyrin

The structure was published by Manjasetty, B.A., Quedenau, C., Sievert, V., et al., Niesen, F., Delbrueck, H., and Heinemann, U., in 2004 in a paper entitled "X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 26S proteasome non-ATPase regulatory subunit 10. This molecule has the UniProt identifier O75832 (PSD10_HUMAN)search. The sample contained 227 residues which is 100% of the natural sequence. Out of 227 residues 221 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 26S proteasome non-ATPase regulatory subunit 10 O75832 (2-226) (PSD10_HUMAN)search Homo sapienssearch 100% 227 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75832 (2 - 226) 26S proteasome non-ATPase regulatory subunit 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O75832) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (O75832) nucleussearch cytosolsearch cytoplasmsearch intermediate filament cytoskeletonsearch proteasome regulatory particle, base subcomplexsearch proteasome regulatory particlesearch nucleoplasmsearch proteasome complexsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch small molecule metabolic processsearch positive regulation of canonical Wnt signaling pathwaysearch positive regulation of cell growthsearch G1/S transition of mitotic cell cyclesearch viral processsearch antigen processing and presentation of exogenous peptide antigen via MHC class Isearch positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transitionsearch antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentsearch negative regulation of apoptotic processsearch negative regulation of DNA damage response, signal transduction by p53 class mediatorsearch cytoplasmic sequestering of NF-kappaBsearch cellular nitrogen compound metabolic processsearch negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch gene expressionsearch positive regulation of protein ubiquitinationsearch mitotic cell cyclesearch apoptotic processsearch proteasome regulatory particle assemblysearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch protein polyubiquitinationsearch regulation of cellular amino acid metabolic processsearch antigen processing and presentation of peptide antigen via MHC class Isearch negative regulation of release of cytochrome c from mitochondriasearch positive regulation of cyclin-dependent protein serine/threonine kinase activitysearch negative regulation of transcription from RNA polymerase II promotersearch regulation of apoptotic processsearch negative regulation of MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch negative regulation of NF-kappaB transcription factor activitysearch protein bindingsearch transcription factor bindingsearch

Chain InterPro annotation
A Ankyrin repeatsearch Ankyrin repeat-containing domainsearch