1qy1 Summary

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Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein

The structure was published by Bingham, R.J., Findlay, J.B.C., Hsieh, S.-Y., et al., Turnbull, W.B., Bodenhausen, G., and Homans, S.W., in 2004 in a paper entitled "Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Major Urinary Protein. This molecule has the UniProt identifier P11588 (MUP1_MOUSE)search. The sample contained 174 residues which is 90% of the natural sequence. Out of 174 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Major Urinary Protein P11588 (19-25) (MUP1_MOUSE)search ,
P11588 (27-34) (MUP1_MOUSE)search ,
P11588 (36-180) (MUP1_MOUSE)search
Mus musculussearch ,
Mus musculussearch ,
Mus musculussearch
90% ,
90% ,
90%
174 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11588 (19 - 25) Major Urinary Protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11588) Retinol binding protein-likesearch Lipocalinsearch PF00061: Lipocalin / cytosolic fatty-acid binding protein familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P11588) pheromone bindingsearch transporter activitysearch small molecule bindingsearch insulin-activated receptor activitysearch transportsearch response to stilbenoidsearch cellular response to testosterone stimulussearch positive regulation of glucose metabolic processsearch aerobic respirationsearch negative regulation of insulin secretion involved in cellular response to glucose stimulussearch locomotor rhythmsearch energy reserve metabolic processsearch negative regulation of gluconeogenesissearch positive regulation of protein kinase B signalingsearch cellular response to foodsearch cellular response to lipidsearch glucose homeostasissearch mitochondrion morphogenesissearch insulin receptor signaling pathwaysearch negative regulation of lipid storagesearch heat generationsearch negative regulation of transcription, DNA-templatedsearch cellular response to starvationsearch positive regulation of gene expressionsearch positive regulation of lipid metabolic processsearch negative regulation of lipid biosynthetic processsearch extracellular regionsearch cytosolsearch extracellular spacesearch nucleussearch

Chain InterPro annotation
A Lipocalin/cytosolic fatty-acid binding domainsearch Lipocalinsearch Major urinary proteinsearch Calycin-likesearch Calycinsearch Lipocalin family conserved sitesearch