1qxp Summary


Crystal Structure of a mu-like calpain

The structure was published by Pal, G.P., Veyra, T.D., Elce, J.S., and Jia, Z., in 2003 in a paper entitled "Crystal Structure of a mu-like calpain reveals a partially activated conformation with low Ca(2+) requirement" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of mu-like calpain.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A mu-like calpain P97571 (60-647) (CAN1_RAT)search Rattus norvegicussearch < 90% 900 87%
B mu-like calpain P97571 (60-647) (CAN1_RAT)search Rattus norvegicussearch < 90% 900 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P97571 (60 - 647) mu-like calpain Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q07009)

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P97571) calcium-dependent cysteine-type endopeptidase activitysearch calcium ion bindingsearch intracellularsearch proteolysissearch

Chain InterPro annotation
A, B Peptidase C2, calpain, catalytic domainsearch EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch Peptidase C2, calpain, large subunit, domain IIIsearch Peptidase C2, calpain, domain IIIsearch Peptidase C2, calpain familysearch Calpain-1search