1qxd Summary

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Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

The structure was published by Safo, M.K., Abdulmalik, O., Danso-Danquah, R., et al., Musayev, F.N., Asakura, T., and Abraham, D.J., in 2004 in a paper entitled "Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch cytosolsearch membranesearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch oxygen transporter activitysearch iron ion bindingsearch peroxidase activitysearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch bicarbonate transportsearch small molecule metabolic processsearch oxygen transportsearch oxidation-reduction processsearch transportsearch
B, D (P68871) extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch protein bindingsearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch heme bindingsearch hemoglobin bindingsearch nitric oxide transportsearch bicarbonate transportsearch positive regulation of cell deathsearch renal absorptionsearch oxygen transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood pressuresearch platelet aggregationsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch