1qxd Summary

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Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

The structure was published by Safo, M.K., Abdulmalik, O., Danso-Danquah, R., et al., Musayev, F.N., Asakura, T., and Abraham, D.J., in 2004 in a paper entitled "Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch oxygen transportsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch bicarbonate transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch small molecule metabolic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch transportsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolic small ribosomal subunitsearch cytosolsearch membranesearch
B, D (P68871) oxygen bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch positive regulation of cell deathsearch bicarbonate transportsearch oxygen transportsearch blood coagulationsearch receptor-mediated endocytosissearch regulation of blood vessel sizesearch small molecule metabolic processsearch protein heterooligomerizationsearch platelet aggregationsearch renal absorptionsearch oxidation-reduction processsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch