1qum Summary

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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA

The structure was published by Hosfield, D.J., Guan, Y., Haas, B.J., Cunningham, R.P., and Tainer, J.A., in 1999 in a paper entitled "Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This entry contains 11 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENDONUCLEASE IV P0A6C1 (1-285) (END4_ECOLI)search Escherichia coli K-12search 100% 285 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A6C1 (1 - 285) ENDONUCLEASE IV Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0A6C1) Endonuclease IVsearch Divalent-metal-dependent TIM barrel enzymessearch PF01261: Xylose isomerase-like TIM barrelsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P0A6C1) DNA bindingsearch zinc ion bindingsearch endonuclease activitysearch metal ion bindingsearch deoxyribonuclease IV (phage-T4-induced) activitysearch phosphoric diester hydrolase activitysearch hydrolase activitysearch nuclease activitysearch DNA-(apurinic or apyrimidinic site) lyase activitysearch DNA repairsearch DNA catabolic process, endonucleolyticsearch nucleic acid phosphodiester bond hydrolysissearch cellular response to DNA damage stimulussearch non-recombinational repairsearch base-excision repairsearch intracellularsearch

Chain InterPro annotation
A AP endonuclease 2search Xylose isomerase-like, TIM barrel domainsearch AP endonuclease 2, zinc binding sitesearch