1qum Summary



The structure was published by Hosfield, D.J., Guan, Y., Haas, B.J., Cunningham, R.P., and Tainer, J.A., in 1999 in a paper entitled "Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This entry contains 11 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENDONUCLEASE IV P0A6C1 (1-285) (END4_ECOLI)search Escherichia coli K-12search 100% 285 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A6C1 (1 - 285) ENDONUCLEASE IV Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0A6C1) Endonuclease IVsearch Divalent-metal-dependent TIM barrel enzymessearch PF01261: Xylose isomerase-like TIM barrelsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P0A6C1) DNA repairsearch base-excision repairsearch DNA catabolic process, endonucleolyticsearch nucleic acid phosphodiester bond hydrolysissearch non-recombinational repairsearch cellular response to DNA damage stimulussearch zinc ion bindingsearch DNA bindingsearch endonuclease activitysearch DNA-(apurinic or apyrimidinic site) lyase activitysearch metal ion bindingsearch deoxyribonuclease IV (phage-T4-induced) activitysearch nuclease activitysearch hydrolase activitysearch phosphoric diester hydrolase activitysearch

Chain InterPro annotation
A AP endonuclease 2search Xylose isomerase-like, TIM barrel domainsearch AP endonuclease 2, zinc binding sitesearch