spacer CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA
UniProt
Accession P0A6C1search
Name END4_ECOLI
Keywords Nuclease, Manganese, 3D-structure, DNA repair, Hydrolase, Endonuclease, Metal-binding, Reference proteome, Zinc, DNA damage, Complete proteome
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Polymers A
 
Enzyme nomenclature
EC number 3.1.21.2 ExPASy BRENDA search
Polymers A
Name deoxyribonuclease IV
Comment The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA. Formerly EC 3.1.4.30.
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