1qsi Summary

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MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME

The structure was published by Miyazaki, G., Morimoto, H., Yun, K.M., et al., Nakagawa, A., Minagawa, H., and Shibayama, N., in 1999 in a paper entitled "Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN ALPHA CHAIN) and PROTEIN (HEMOGLOBIN BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch iron ion bindingsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch oxygen transportsearch protein heterooligomerizationsearch transportsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch membranesearch extracellular regionsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch
B, D (P68871) iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transportsearch positive regulation of cell deathsearch bicarbonate transportsearch small molecule metabolic processsearch regulation of blood vessel sizesearch platelet aggregationsearch oxidation-reduction processsearch regulation of blood pressuresearch receptor-mediated endocytosissearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch blood coagulationsearch transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch