1qsh Summary

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MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME

The structure was published by Miyazaki, G., Morimoto, H., Yun, K.M., et al., Nakagawa, A., Minagawa, H., and Shibayama, N., in 1999 in a paper entitled "Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN ALPHA CHAIN) and PROTEIN (HEMOGLOBIN BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch small molecule metabolic processsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch membranesearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch
B, D (P68871) response to hydrogen peroxidesearch regulation of blood vessel sizesearch platelet aggregationsearch hydrogen peroxide catabolic processsearch oxygen transportsearch regulation of blood pressuresearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch nitric oxide transportsearch blood coagulationsearch oxidation-reduction processsearch receptor-mediated endocytosissearch transportsearch extracellular regionsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch