1qsg Summary

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CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN

The structure was published by Stewart, M.J., Parikh, S., Xiao, G., Tonge, P.J., and Kisker, C., in 1999 in a paper entitled "Structural basis and mechanism of enoyl reductase inhibition by triclosan." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
B ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
C ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
D ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
E ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
F ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
G ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%
H ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE P0AEK4 (1-262) (FABI_ECOLI)search Escherichia coli K-12search 100% 265 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0AEK4 (1 - 262) ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P0AEK4) Tyrosine-dependent oxidoreductasessearch NAD(P)-binding Rossmann-like Domainsearch PF13561: Enoyl-(Acyl carrier protein) reductasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D, E, F, G, H (P0AEK4) lipid biosynthetic processsearch lipid metabolic processsearch biotin biosynthetic processsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch oxidation-reduction processsearch fatty acid elongationsearch protein homotetramerizationsearch response to antibioticsearch membranesearch enoyl-[acyl-carrier-protein] reductase (NADH) activitysearch oxidoreductase activitysearch identical protein bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Glucose/ribitol dehydrogenasesearch Enoyl-[acyl-carrier-protein] reductase (NADH)search NAD(P)-binding domainsearch