1qrl Summary

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A CLOSER LOOK AT THE ACTIVE SITE OF GAMMA-CARBONIC ANHYDRASES: HIGH RESOLUTION CRYSTALLOGRAPHIC STUDIES OF THE CARBONIC ANHYDRASE FROM METHANOSARCINA THERMOPHILA

The structure was published by Iverson, T.M., Alber, B.E., Kisker, C., Ferry, J.G., and Rees, D.C., in 2000 in a paper entitled "A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P40881 (CAH_METTE)search. The sample contained 214 residues which is 100% of the natural sequence. Out of 214 residues 212 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P40881 (35-247) (CAH_METTE)search Methanosarcina thermophilasearch 100% 214 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P40881 (35 - 247) CARBONIC ANHYDRASE Methanosarcina thermophila

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P40881) gamma-carbonic anhydrase-likesearch Hexapeptide repeat proteinssearch PF00132: Bacterial transferase hexapeptide (six repeats)search, PF14602: Hexapeptide repeat of succinyl-transferasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P40881) carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch metabolic processsearch

Chain InterPro annotation
A Bacterial transferase hexapeptide repeatsearch Trimeric LpxA-likesearch