1qrk Summary

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PDB entry 1qrk (supersedes 1bl2)

HUMAN FACTOR XIII WITH STRONTIUM BOUND IN THE ION SITE

The structure was published by Fox, B.A., Yee, V.C., Pedersen, L.C., et al., Bishop, P.D., Stenkamp, R.E., and Teller, D.C., in 1999 in a paper entitled "Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (COAGULATION FACTOR XIII).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (COAGULATION FACTOR XIII) P00488 (2-732) (F13A_HUMAN)search Homo sapienssearch 100% 731 96%
B PROTEIN (COAGULATION FACTOR XIII) P00488 (2-732) (F13A_HUMAN)search Homo sapienssearch 100% 731 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00488 (2 - 732) PROTEIN (COAGULATION FACTOR XIII) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00488) Transglutaminase N-terminal domainsearch, Transglutaminase, two C-terminal domainssearch, Transglutaminase coresearch Immunoglobulinssearch, Coagulation Factor XIII, subunit A, domain 2search PF00868: Transglutaminase familysearch, PF00927: Transglutaminase family, C-terminal ig like domainsearch, PF01841: Transglutaminase-like superfamilysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P00488) peptide cross-linkingsearch blood coagulationsearch hemostasissearch platelet degranulationsearch platelet activationsearch cytoplasmsearch extracellular regionsearch platelet alpha granule lumensearch blood microparticlesearch transferase activitysearch transferase activity, transferring acyl groupssearch protein-glutamine gamma-glutamyltransferase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Transglutaminase, N-terminalsearch Transglutaminase-likesearch Transglutaminase, C-terminalsearch Immunoglobulin-like foldsearch Transglutaminase, conserved sitesearch Immunoglobulin E-setsearch Protein-glutamine gamma-glutamyltransferase, eukaryotasearch