1qpj Summary

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CRYSTAL STRUCTURE OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH STAUROSPORINE.

The structure was published by Zhu, X., Kim, J.L., Newcomb, J.R., et al., Toledo, L.M., Zhao, H., and Morgenstern, K.A., in 1999 in a paper entitled "Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of LCK TYROSINE KINASE. This molecule has the UniProt identifier P06239 (LCK_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 264 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LCK TYROSINE KINASE P06239 (231-509) (LCK_HUMAN)search Homo sapienssearch < 90% 279 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06239 (231 - 509) LCK TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P06239) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch