1qol Summary

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STRUCTURE OF THE FMDV LEADER PROTEASE

The structure was published by Guarne, A., Tormo, J., Kirchweger, R., Pfistermueller, D., Fita, I., and Skern, T., in 1998 in a paper entitled "Structure of the Foot-and-Mouth Disease Virus Leader Protease: A Papain-Like Fold Adapted for Self-Processing and Eif4G Recognition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEASE (NONSTRUCTURAL PROTEIN P20A).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
B PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
C PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
D PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
E PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
F PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
G PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%
H PROTEASE (NONSTRUCTURAL PROTEIN P20A) P03305 (29-201) (POLG_FMDVO)search Foot-and-mouth disease virus (strain O1)search < 90% 173 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03305 (29 - 201) PROTEASE (NONSTRUCTURAL PROTEIN P20A) Foot-and-mouth disease virus (strain O1)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H FMDV leader proteasesearch Cysteine proteinasessearch Foot-and-mouth virus L-proteinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H (P03305) cysteine-type endopeptidase activitysearch viral processsearch viral protein processingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Peptidase C28, foot-and-mouth virus L-proteinasesearch