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STRUCTURE OF THE FMDV LEADER PROTEASE

X-ray diffraction
3Å resolution
PDB entry 1qol coloured by chain, front view.
PDB entry 1qol coloured by chain, side view.
PDB entry 1qol coloured by chain, top view.
Source organism: Foot-and-mouth disease virus (strain O1)
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Leader protease
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Multimeric state: homo dimer
Accessible surface area: 15138.77 Å2
Buried surface area: 3162.87 Å2
Dissociation area: 1,510.44 Å2
Dissociation energy (ΔGdiss): 7.13 kcal/mol
Dissociation entropy (TΔSdiss): 12.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136753
Assembly 2 (preferred)
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Assembly Name: Leader protease
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Multimeric state: homo dimer
Accessible surface area: 15143.04 Å2
Buried surface area: 3388.57 Å2
Dissociation area: 1,512.62 Å2
Dissociation energy (ΔGdiss): 7.26 kcal/mol
Dissociation entropy (TΔSdiss): 12.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136753
Assembly 3
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Assembly Name: Leader protease
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Multimeric state: homo dimer
Accessible surface area: 15187.61 Å2
Buried surface area: 3079.84 Å2
Dissociation area: 1,465.86 Å2
Dissociation energy (ΔGdiss): 7.22 kcal/mol
Dissociation entropy (TΔSdiss): 12.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136753
Assembly 4
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Assembly Name: Leader protease
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Multimeric state: homo dimer
Accessible surface area: 15103.31 Å2
Buried surface area: 2946.59 Å2
Dissociation area: 1,417.52 Å2
Dissociation energy (ΔGdiss): 8.76 kcal/mol
Dissociation entropy (TΔSdiss): 12.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136753

Macromolecules

Leader protease
Chains: A, B, C, D, E, F, G, H
Length: 173 amino acids
Theoretical weight: 19.78 KDa
Source organism: Foot-and-mouth disease virus (strain O1)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03305 (Residues: 29-201; Coverage: 7%)
Pfam: Foot-and-mouth virus L-proteinase
InterPro:
CATH: Cysteine proteinases
SCOP: FMDV leader protease
Leader protease in PDB entry 1qol, assembly 2, front view.
Leader protease in PDB entry 1qol, assembly 2, side view.
Leader protease in PDB entry 1qol, assembly 2, top view.
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