1qmz Summary

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PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX

The structure was published by Brown, N.R., Noble, M.E., Endicott, J.A., and Johnson, L.N., in 1999 in a paper entitled "The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, and SUBSTRATE PEPTIDE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
B G2/MITOTIC-SPECIFIC CYCLIN A P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
D G2/MITOTIC-SPECIFIC CYCLIN A P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
E SUBSTRATE PEPTIDE Not available
HOMO SAPIENSsearch Not available 7 100%
F SUBSTRATE PEPTIDE Not available
HOMO SAPIENSsearch Not available 7 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) G2/MITOTIC-SPECIFIC CYCLIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch
E, F

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P24941) protein phosphorylationsearch meiotic nuclear divisionsearch cellular response to nitric oxidesearch mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch blood coagulationsearch G2/M transition of mitotic cell cyclesearch mitotic nuclear divisionsearch cellular response to DNA damage stimulussearch DNA replicationsearch mitotic G1 DNA damage checkpointsearch G1/S transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of transcription, DNA-templatedsearch potassium ion transportsearch histone phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene silencingsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch Ras protein signal transductionsearch cell cyclesearch DNA repairsearch centrosome duplicationsearch phosphorylationsearch cell divisionsearch positive regulation of cell proliferationsearch cytoplasmsearch nucleoplasmsearch transcription factor complexsearch endosomesearch X chromosomesearch centrosomesearch cytosolsearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch Y chromosomesearch microtubule organizing centersearch Cajal bodysearch chromosome, telomeric regionsearch condensed chromosomesearch protein kinase activitysearch kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch ATP bindingsearch histone kinase activitysearch transferase activitysearch metal ion bindingsearch nucleotide bindingsearch
B, D (P20248) regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch protein kinase bindingsearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch
E, F