1qls Summary

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S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS

The structure was published by Rety, S., Osterloh, D., Arie, J.P., et al., Russo-Marie, F., Gerke, V., and Lewit-Bentley, A., in 2000 in a paper entitled "Structural Basis of the Ca2+ Dependent Association between S100C (S100A11) and its Target, the N-Terminal Part of Annexin I" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely S100C PROTEIN and ANNEXIN I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S100C PROTEIN P31950 (1-99) (S10AB_PIG)search Sus scrofasearch 100% 99 95%
D ANNEXIN I P04083 (2-12) (ANXA1_HUMAN)search Homo sapienssearch 91% 12 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P31950 (1 - 99) S100C PROTEIN Sus scrofa
P04083 (2 - 12) ANNEXIN I HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P31950) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
D (P04083)

Chain ID Molecular function (GO) Cellular component (GO)
A (P31950) calcium ion bindingsearch metal ion bindingsearch cytoplasmsearch nucleussearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch
D