1qha Summary

pdbe.org/1qha
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HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP

The structure was published by Rosano, C., Sabini, E., Rizzi, M., et al., Serafini, G., Magnani, M., and Bolognesi, M., in 1999 in a paper entitled "Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (HEXOKINASE).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEXOKINASE) P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 98%
B PROTEIN (HEXOKINASE) P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19367 (1 - 917) PROTEIN (HEXOKINASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P19367) Hexokinasesearch Nucleotidyltransferase; domain 5search, Hexokinase; domain 1search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P19367) membranesearch mitochondrial outer membranesearch mitochondrionsearch cytosolsearch hexose metabolic processsearch transmembrane transportsearch carbohydrate phosphorylationsearch cell deathsearch carbohydrate metabolic processsearch cellular glucose homeostasissearch glycolytic processsearch glucose 6-phosphate metabolic processsearch phosphorylationsearch glucose transportsearch metabolic processsearch small molecule metabolic processsearch hexose transportsearch ATP bindingsearch mannokinase activitysearch hexokinase activitysearch kinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch fructokinase activitysearch protein bindingsearch transferase activitysearch glucokinase activitysearch nucleotide bindingsearch catalytic activitysearch

Chain InterPro annotation
A, B Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch