1qg1 Summary

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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE

The structure was published by Ogura, K., Tsuchiya, S., Terasawa, H., et al., Mandiyan, V., Schlessinger, J., and Inagaki, F., in 1999 in a paper entitled "Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN) and PROTEIN (SHC-DERIVED PEPTIDE).

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN) P62993 (58-159) (GRB2_HUMAN)search Homo sapienssearch 100% 104 100%
I PROTEIN (SHC-DERIVED PEPTIDE) P29353 (423-435) (SHC1_HUMAN)search Homo sapienssearch < 90% 13 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62993 (58 - 159) PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN) Homo sapiens
P29353 (423 - 435) PROTEIN (SHC-DERIVED PEPTIDE)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
I
Chain InterPro annotation
E SH2 domainsearch
I