› 1qd3

Solution NMR

HIV-1 TAR RNA/NEOMYCIN B COMPLEX

Released:
DOI: 10.2210/pdb1qd3/pdb
PDB entry 1qd3 coloured by chain, ensemble of 17 models, front view.
PDB entry 1qd3 coloured by chain, ensemble of 17 models, side view.
PDB entry 1qd3 coloured by chain, ensemble of 17 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B.
Faber C, Sticht H, Schweimer K, Rösch P
J Biol Chem 275 20660-6 (2000)
PMID: 10747964

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196177 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecules (2 distinct):
HIV-1 TAR RNA Chain: A
Molecule details ›
Chain: A
Length: 29 nucleotides
Theoretical weight: 9.31 KDa
Source organism: Human immunodeficiency virus 1

Ligands and Environments

Carbohydrate polymer : NEW Components: RIB, IDG
Carbohydrate polymer
2 bound ligands:
Ligand BDG 1 x BDG
Ligand CYY 1 x CYY
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics

Quick links

Citations

12 review citations

Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.
Deigan et al. (2011)
11 more

17 mentions without citation

Principles for targeting RNA with drug-like small molecules.
Warner et al. (2018)
16 more