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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE

Source organism: Mus musculus
Biochemical function: metal ion binding
Biological process: homogentisate catabolic process
Cellular component: not assigned

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EC 3.7.1.2: Fumarylacetoacetase

Reaction catalysed:
4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate
Systematic name:
4-fumarylacetoacetate fumarylhydrolase
Alternative Name(s):
  • Beta-diketonase
  • Fumarylacetoacetate hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01557
Domain description: Fumarylacetoacetate (FAA) hydrolase family
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of Pfam domain PF01557 (Fumarylacetoacetate (FAA) hydrolase family) in Fumarylacetoacetase. Showing 1 copy in chain B.

PF09298
Domain description: Fumarylacetoacetase N-terminal
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of Pfam domain PF09298 (Fumarylacetoacetase N-terminal) in Fumarylacetoacetase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036663
Domain description: Fumarylacetoacetase-like, C-terminal domain superfamily
Occurring in:
  1. Fumarylacetoacetase
IPR005959
Domain description: Fumarylacetoacetase
Occurring in:
  1. Fumarylacetoacetase
IPR036462
Domain description: Fumarylacetoacetase, N-terminal domain superfamily
Occurring in:
  1. Fumarylacetoacetase
IPR011234
Domain description: Fumarylacetoacetase-like, C-terminal
Occurring in:
  1. Fumarylacetoacetase
IPR015377
Domain description: Fumarylacetoacetase, N-terminal
Occurring in:
  1. Fumarylacetoacetase

Structure domains

CATH CATH domains
3.90.850.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Fumarylacetoacetate hydrolase; domain 2
Homology: Fumarylacetoacetase-like, C-terminal domain
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of CATH domain 3.90.850.10 (Fumarylacetoacetate hydrolase; domain 2) in Fumarylacetoacetase. Showing 1 copy in chain B.
2.30.30.230
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Fumarylacetoacetase, N-terminal domain
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of CATH domain 2.30.30.230 (SH3 type barrels.) in Fumarylacetoacetase. Showing 1 copy in chain B.
SCOP SCOP annotations
56530
Class: Alpha and beta proteins (a+b)
Fold: FAH
Superfamily: FAH
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of SCOP domain 56530 (FAH) in Fumarylacetoacetase. Showing 1 copy in chain B.
63434
Class: All beta proteins
Fold: SH3-like barrel
Superfamily: Fumarylacetoacetate hydrolase, FAH, N-terminal domain
Occurring in:
  1. Fumarylacetoacetase
The deposited structure of PDB entry 1qcn contains 2 copies of SCOP domain 63434 (Fumarylacetoacetate hydrolase, FAH, N-terminal domain) in Fumarylacetoacetase. Showing 1 copy in chain B.

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