Function and Biology Details
Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Phosphoinositide phospholipase C family
- C2 domain
- EF-hand domain
- C2 domain superfamily
- Phospholipase C, phosphatidylinositol-specific, Y domain
- Phosphatidylinositol-specific phospholipase C, X domain
- PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
- EF-Hand 1, calcium-binding site
4 more domains
Structure domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145423 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Molecule details ›
Chains: A, B
Length: 622 amino acids
Theoretical weight: 70.43 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 622 amino acids
Theoretical weight: 70.43 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P10688 (Residues: 135-756; Coverage: 82%)
Sequence domains:
- Phosphoinositide-specific phospholipase C, efhand-like
- Phosphatidylinositol-specific phospholipase C, X domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- C2 domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RUH2R
Spacegroup:
P1
Expression system: Escherichia coli
