1q8w Summary

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The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)

The structure was published by Breitenlechner, C., Gassel, M., Hidaka, H., et al., Huber, R., Engh, R.A., and Bossemeyer, D., in 2003 in a paper entitled "Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase, alpha-catalytic subunit and cAMP-dependent protein kinase inhibitor, alpha form.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase, alpha-catalytic subunit P00517 (2-351) (KAPCA_BOVIN)search Bos taurussearch 96% 350 96%
B cAMP-dependent protein kinase inhibitor, alpha form P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (2 - 351) cAMP-dependent protein kinase, alpha-catalytic subunit Bos taurus
P61926 (6 - 25) cAMP-dependent protein kinase inhibitor, alpha form

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00517) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
B cAMP-dependent protein kinase inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00517) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch cAMP-dependent protein kinase activitysearch ubiquitin protein ligase bindingsearch kinase activitysearch transferase activitysearch protein kinase bindingsearch nucleotide bindingsearch protein bindingsearch protein serine/threonine/tyrosine kinase activitysearch protein kinase A regulatory subunit bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch cellular response to glucose stimulussearch mesoderm formationsearch regulation of tight junction assemblysearch cellular response to parathyroid hormone stimulussearch sperm capacitationsearch phosphorylationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch neural tube closuresearch protein autophosphorylationsearch positive regulation of protein export from nucleussearch regulation of protein processingsearch positive regulation of cell cycle arrestsearch peptidyl-serine phosphorylationsearch peptidyl-threonine phosphorylationsearch regulation of osteoblast differentiationsearch regulation of synaptic transmissionsearch regulation of proteasomal protein catabolic processsearch nucleussearch membranesearch ciliary basesearch plasma membranesearch extracellular vesicular exosomesearch AMP-activated protein kinase complexsearch neuromuscular junctionsearch cytoplasmsearch mitochondrionsearch centrosomesearch sperm midpiecesearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B cAMP-dependent protein kinase inhibitorsearch