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PDBe Entry: 1q8u 
The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P
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Transferase/Transferase Inhibitor
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X-RAY DIFFRACTION
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Resolution: 1.9 Å, R-factor: 17.3%, Free R-factor: 20.6%, Spacegroup: P 21 21 21
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16/12/2003, deposition: 22/08/2003, last revision: 24/02/2009
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Breitenlechner, C.; Gassel, M.; Hidaka, H.; Kinzel, V.; Huber, R.; Engh, R.A.; Bossemeyer, D.
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Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
STRUCTURE vol:11, pag:1595-1607 (2003) [PubMed ID 14656443 ]
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KINASE-INHIBITOR-COMPLEX, PHOSPHOTRANSFERASE/INHIBITOR, CAMP, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PKA, RHO-KINASE, Transferase/Transferase Inhibitor COMPLEX
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2.7.11.11 ExPASy BRENDA (A)
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Bos taurus(cattle) 9913(A)
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cAMP-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11) (PKA C-alpha) P00517 (A)
cAMP-dependent protein kinase inhibitor alpha (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) (PKI-alpha) P61925 (B)
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A, B
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1q8t, 1q8w
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| A |
cAMP-dependent protein kinase, alpha-catalytic subunit |
Protein |
P00517 (KAPCA_BOVIN)
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350 |
98% |
| B |
cAMP-dependent protein kinase inhibitor, alpha form |
Protein |
P61925 (IPKA_HUMAN)
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20 |
100% |
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| A |
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE |
H52
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| A |
N-OCTANOYL-N-METHYLGLUCAMINE |
MG8
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