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Zn-binding domain of the T347G mutant of human aminoacylase-I

X-ray diffraction
1.4Å resolution
PDB entry 1q7l coloured by chain, front view.
PDB entry 1q7l coloured by chain, side view.
PDB entry 1q7l coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Aminoacylase-1
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Multimeric state: hetero dimer
Accessible surface area: 12063.66 Å2
Buried surface area: 7210.25 Å2
Dissociation area: 3,512.92 Å2
Dissociation energy (ΔGdiss): 71.21 kcal/mol
Dissociation entropy (TΔSdiss): 12.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169851
Assembly 2 (preferred)
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Assembly Name: Aminoacylase-1
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Multimeric state: hetero dimer
Accessible surface area: 12180.45 Å2
Buried surface area: 7103.86 Å2
Dissociation area: 3,507.05 Å2
Dissociation energy (ΔGdiss): 72.25 kcal/mol
Dissociation entropy (TΔSdiss): 12.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169851
Assembly 3
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Assembly Name: Aminoacylase-1
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Multimeric state: hetero tetramer
Accessible surface area: 21275.43 Å2
Buried surface area: 17282.78 Å2
Dissociation area: 1,549.54 Å2
Dissociation energy (ΔGdiss): 28.51 kcal/mol
Dissociation entropy (TΔSdiss): 13.42 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-169852

Macromolecules

Aminoacylase-1
Chains: A, C
Length: 198 amino acids
Theoretical weight: 22.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q03154 (Residues: 1-198; Coverage: 49%)
Gene name: ACY1
Pfam: Peptidase family M20/M25/M40
InterPro:
CATH: Zn peptidases
SCOP: Bacterial dinuclear zinc exopeptidases
Aminoacylase-1 in PDB entry 1q7l, assembly 2, front view.
Aminoacylase-1 in PDB entry 1q7l, assembly 2, side view.
Aminoacylase-1 in PDB entry 1q7l, assembly 2, top view.
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Aminoacylase-1
Chains: B, D
Length: 88 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q03154 (Residues: 321-408; Coverage: 22%)
Gene name: ACY1
InterPro: Peptidase M20
CATH: DNA polymerase; domain 1
SCOP: Bacterial dinuclear zinc exopeptidases
Aminoacylase-1 in PDB entry 1q7l, assembly 2, front view.
Aminoacylase-1 in PDB entry 1q7l, assembly 2, side view.
Aminoacylase-1 in PDB entry 1q7l, assembly 2, top view.
Molecule details ›

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