1q6x Summary


Crystal structure of rat choline acetyltransferase

The structure was published by Cai, Y., Cronin, C.N., Engel, A.G., Ohno, K., Hersh, L.B., and Rodgers, D.W., in 2004 in a paper entitled "Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of choline O-acetyltransferase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A choline O-acetyltransferase P32738 (1-634) (CLAT_RAT)search Rattus norvegicussearch 99% 644 93%
B choline O-acetyltransferase P32738 (1-634) (CLAT_RAT)search Rattus norvegicussearch 99% 644 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P32738 (1 - 634) choline O-acetyltransferase Rattus norvegicus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P32738) Choline/Carnitine O-acyltransferasesearch PF00755: Choline/Carnitine o-acyltransferasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P32738) transferase activity, transferring acyl groupssearch choline O-acetyltransferase activitysearch transferase activitysearch choline bindingsearch acetylcholine biosynthetic processsearch neurotransmitter biosynthetic processsearch response to hypoxiasearch response to ethanolsearch antral ovarian follicle growthsearch memorysearch response to drugsearch response to nutrientsearch neuron projectionsearch

Chain InterPro annotation
A, B Acyltransferase ChoActase/COT/CPTsearch