Function and Biology Details
Reaction catalysed:
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
homo hexamer (preferred)
Assembly name:
1,4-dihydroxy-2-naphthoyl-CoA synthase (preferred)
PDBe Complex ID:
PDB-CPX-161875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1,4-dihydroxy-2-naphthoyl-CoA synthase
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 314 amino acids
Theoretical weight: 34.73 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:
Length: 314 amino acids
Theoretical weight: 34.73 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
- Canonical:
P9WNP5 (Residues: 1-314; Coverage: 100%)
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X26C
Spacegroup:
P21
Expression system: Escherichia coli
